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Salmonella enteridis

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Topic updated on 11/01/17 8:03am

Introduction
  • Classification
    • Bacteria
      • Gram-negative bacilli
        • The Enterics
          • facultative anaerobes
            • Enterobacteriaceae
              • non-lactose fermenting
              • Salmonella
                • S. enteridis
  • Pathogenesis
    • transmission
      • chicken products (eggs, raw chicken)
      • reptile pets
    • reservoir
      • GI tracts of domesticated animals and humans
        • chickens, turtles
    • molecular biology
      • Vi antigen
        • blocks antibody attack on O antigen 
      • invades mucosa in ileocecal region
      • endotoxin in cell wall
        • no exotoxin
      • sensitive to stomach acid
        • large infectious dose needed
      • motile
        • flagella allow heterogenous dissemination ("salmon swim")
Diseases
  • Enterocolitis/gastroenteritis
    • 2nd most common cause after campylobacter
    • 6-48 hour incubation followed by
      • nausea/vomiting
      • sometimes bloody, loose stools
      • fever
      • abdominal pain, myalgia, headache
    • disease is self-limiting
      • antibiotics are contraindicated
  • Septicemia
    • in very young or elderly
  • Osteomyelitis
    • most common causative agent of osteomyelitis in sickle cell disease
Laboratory
  • Vi antigen can be detected with Widal test
    • found in Salmonella typhi and paratyphi
  • Produces H2S gas
  • Non-lactose fermenting
Treatment
  • Gastroenteritis is self-limiting
    • antibiotics are contraindicated
  • Ampicillin, fluoroquinolones, third-generation cephalosporins for severe infections


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