- ↑ cGMP → smooth muscle relaxation
- results in ↓ TPR
- can stimulate reflex tachycardia
- frequently coadministered with a β-blocker to inhibit compensatory action
- vasodilates arterioles > veins
- Clinical use
- moderate/severe hypertension
- ↓ afterload
- hypertension in pregnancy
- contraindicated in angina/CAD
- fluid retention
- lupus-like syndrome (especially for slow acetylators)
- K+-channel opener
- hyperpolarizes and relaxes vascular smooth muscle
- Clinical use
- active ingredient in topical Rogaine
- pericardial effusion
- reflex tachycardia
- salt retention
AVERAGE 0.0 of 0 RATINGS
Qbank (0 Questions)
Level of Evidence 5 and Other Journal Articles (includes Case Reports, Expert Opinions,
Personal Observations, and Biomechanic Studies)
Chavey WE, Bleske BE, Van Harrison R, Hogikyan RV, Kesterson SK, Nicklas JM. Pharmacologic management of heart failure caused by systolic dysfunction. Am Fam Physician. 2008 Apr 1;77(7):957-64.
PMID:18441861 (Link to Abstract)
Farag M, Mabote T, Shoaib A, Zhang J, Nabhan AF, Clark AL, Cleland JG. Hydralazine and nitrates alone or combined for the management of chronic heart failure: A systematic review. Int J Cardiol. 2015 Oct 1;196:61-9.
PMID:26073215 (Link to Abstract)
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