questions 5

CNS Development

Author:
Topic updated on 05/04/17 12:02pm

 
 
 
Overview
  • CNS development (week 3)
    •  neuroectoderm (a subtype of ectoderm) → neural plate → brain and spinal cord 
  • Neural tube gives rise to
    • forebrain (prosencephalon) 
      • telencephalon 
        • cerebral cortex, lateral ventricles, caudate, putamen, hippocampus, olfactory bulbs
      • diencephalon
        • thalami, mammillary bodies, neurohypophysis, pineal gland, retina, optic nerve, chiasm, and tract
    • midbrain (mesencephalon)
    • hindbrain (rhombencephalon)
      • metencephalon
        • pons, cerebellum
      • mylencephalon
        • medulla
Neural tube defects
 
 
  • Failure of neuropores to fuse during week 4
    • vertebral arches do not fuse resulting in a connection between amnionic cavity and spinal canal
    • defect tends to occur in lumbosacral region
    • can be detected by testing maternal blood for ↑ α-fetoprotein (AFP)
      • if elevated and neural tube defect is present, then amniocentesis will show ↑ α-fetoprotein (AFP) and ↑ acetylcholinesterase 
    • associated with maternal folate deficiency commonly caused by: 
      • low folic acid intake during pregnancy 
      • medications that interfere with folate utilization 
        • Valproate, methotrexate, sulfasalazine, phenytoin
  • Spina bifida oculta
    • least severe variation with dura intact and no herniation
    • tuft of hair in lumbosacral region 
  • Spina bifida with meningocele
    • only meninges herniate through spinal defect forming a CSF filled sac, but spinal cord remains in spinal canal
  • Spina bifida with meningomyelocele
    • meninges and spinal cord herniate through defect


  RATE CONTENT
5.0
AVERAGE 5.0 of 5 RATINGS

Qbank (1 Questions)

TAG
(M1.EB.6) A 24-year-old female with a history of recurrent infections, bipolar disorder, and no prenatal care gives birth to a male infant. On physical exam in the delivery room, you observe a tuft of hair over the infant's lumbosacral region. Which of the following drugs was this mother most likely taking during pregnancy? Topic Review Topic

1. Chloramphenicol
2. Gentamicin
3. Lithium
4. Valproate
5. Folic acid

PREFERRED RESPONSE ▶
Sorry, this question is only available for Study Plan members.
Access to 600+ Questions not available in Free Qbank

This is a Never-Been-Seen Question that can only be seen in Study Plan Mock Exams.
Access to 600+ Questions not available in Free Qbank


Recent Videos

video
Great presentation
10/16/2016
99 views
5
video
good
10/11/2015
121 views
4

Evidence & References Show References




Topic Comments

Subscribe status: