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Pancreas and Spleen Embryology

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Topic updated on 04/07/17 9:52pm

 
 This illustrations shows the embryological development of the pancreas. The ventral bud rotates dorsally to meet the dorsal bud, and then the two fuse to form the adult pancreas. 
Pancreas
  • Normal embryology
    • outgrowth of foregut endoderm induced by notochord
      • ventral pancreatic bud forms
        • pancreatic head
        • uncinate process
        • main pancreatic duct
      • dorsal pancreatic bud forms
        • body
        • tail
        • isthmus
        • accessory pancreatic duct
      • ventral bud rotates dorsally to fuse with dorsal bud
Spleen
  • Mesodermal in origin
  • Derived from dorsal mesentery
  • Supplied by splenic artery which is a branch of the celiac artery
    • travels within the splenorenal ligament
Pathology
  • Annular pancreas
    • ventral and dorsal buds fuse both dorsally and ventrally, encircling the 2nd part of duodenum
    • may cause duodenal narrowing
    • emesis is usually nonbilious
  • Pancreas divisum
    • ventral and dorsal buds fail to fuse, forming two separate pancreatic systems
    • prone to pancreatitis
  • Accessory pancreatic duct
    • dorsal pancreatic duct opens into duodenum


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