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Adrenal Cortex and Medulla

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Topic updated on 05/30/17 8:51am

Overview 
 
Primary Regulatory Control
Anatomy
Secretory products
Renin-angiotensin Zona glomerulosa Aldosterone
ACTH, hypothalamic CRH Zona fasciculata Cortisol and sex hormones
ACTH, hypothalamic CRH Zona reticularis Sex hormones (e.g. androgens)
Preganglionic sympathetic fibers Medulla Catecholamines (Epi, NE)
  • Glomerulosa (salt), fasciculata (sugar), reticularis (sex)
    • "The deeper you go, the sweeter it gets." 
Adrenal Circulation
  • Both the left and right adrenals receive arterial blood supply in the same fashion
    • Paired superior suprarenal arteries - derived from inferior phrenic arteries
    • Paired middle suprarenal arteries - derived directly from abdominal aorta
    • Paired inferior suprarenal arteris - derived from the adjacent renal arteries
  • The left and right adrenals have differing venous drainage
    • The left adrenal venous drainage is through the left adrenal vein to the left renal vein and finally to the IVC
    • The right adrenal venous drainage is through the right adrenal vein to the IVC
  • Recall the same pattern for the left and right gonadal artery/vein
 
Selected Pathology
  • Pheochromocytoma
  • Neuroblastoma
  • Conn's syndrome
  • Cushing's syndrome
  • Addison's disease


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Qbank (1 Questions)

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(M1.EC.70) A 54-year-old woman appears in your office for a new patient visit. She reports a past medical history of hypertension, which she was told was related to "adrenal gland disease." You recall that Conn syndrome and pheochromocytomas are both conditions affecting the adrenal gland that result in hypertension by different mechanisms. Which areas of the adrenal gland are involved in Conn syndrome and pheochromocytomas, respectively? Topic Review Topic

1. Zona glomerulosa; zona fasciculata
2. Zona fasciculata; medulla
3. Zona glomerulosa; medulla
4. Medulla; zona reticularis
5. Zona fasciculata; zona reticularis

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