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Prolactin

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Topic updated on 07/20/17 7:57am

Overview
  • Secretion 
    • released from anterior pituitary
  • Regulation
    • release is inhibited by dopamine from hypothalamus 
      • dopamine agonists (bromocriptine) inhibit prolactin secretion and are the treatment for hyperprolactinemia
      • dopamine antagonists (most antipsychotics) stimulate prolactin secretion by decreasing inhibition by dopamine
      • prolactin increases dopamine synthesis and secretion from hypothalamus
      • TRH ↑ prolactin secretion
        • seen in hypothyroidism
  • Function
    • stimulates milk production
      • recall oxytocin responsible for ejection of milk
    • inhibits ovulation/spermatogenesis
      • via inhibition of GnRH
      • functions as a natural contraception during breast feeding


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Qbank (1 Questions)

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(M1.EC.75) A 43-year-old man with a history of schizophrenia, currently controlled with medication, comes in for an appointment with his internist. He is concerned about abnormal discharge from both nipples over the past 3 months. The fluid is white, and he wonders if it could be milk. On further review of systems, he endorses a diminished sexual drive. The physician suspects that one of the patient's medications may be the culprit for these symptoms. Which of the following medications is NOT likely to be the cause? Topic Review Topic

1. metoclopramide
2. haloperidol
3. bromocriptine
4. fluphenazine
5. risperidone

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