questions 2

Signaling Pathways of Endocrine Hormones

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Topic updated on 06/07/16 6:57pm

Overview
  • General mechanism
    • releasing hormone (IP3) → pituitary hormone (cAMP) → systemic hormone (steroid)
      • GnRH → FSH/LH → estrogen/testosterone/progesterone 
      • TRH → TSH →T3/T4
    • vasoactive hormones
      • cGMP
    • growth factors
      • tyrosine kinase
    • growth hormone, cytokines, hormones
      • receptor tyrosine kinase

IP3
cAMP
cGMP Tyrosine kinase - intrinsic Tyrosine kinase - receptor associated Steroid
GnRH

FSH

ANP Insulin Prolactin Glucocorticoid
Gastrin
LH NO (EDRF)
IGF-1 Cytokines (IL-2,6,8) Estrogen
Oxytocin ACTH   FGF GH Progesterone
TRH TSH   PDGF   Testosterone
ADH (V1) CRH  
  Aldosterone
 Histamine (H1)
hCG  
  Vitamin D
 Angiotensin II
PTH  
  T3/T4
  Calcitonin        Cortisol
  Glucagon        
  GHRH (can act via IP3 as well)        
 


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Qbank (1 Questions)

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(M1.EC.73) A 16-year-old male comes to his doctor worried that he has not yet gone through puberty. He feels that his genitals are less developed than they should be for his age. On physical exam, you note an absence of facial hair and that his voice has not yet deepened. Your exam confirms that he is Tanner Stage 1. On a thorough review of systems, you learn that the patient has lacked a sense of smell from birth. Which of the following is implicated in the development of this patient's underlying condition? Topic Review Topic

1. Chromosomal duplication
2. Expansile suprasellar tumor
3. Exposure to radiation
4. Failure of normal neuronal migration during development
5. Defect in steroid production

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