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Hypothalamic/Pituitary Drugs

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Topic updated on 09/06/16 7:50pm

Somatropin
  • Growth hormone (GH) mimetic
  • Mechanism
    • agonist at GH receptors
    • increases production of insulin growth factor-1 (IGF-1)
  • Clinical use
    • GH deficiency
    • increase adult height for children with conditions associated with short stature 
      • Turner syndrome
    • wasting in HIV infection
    • short bowel syndrome
  • Toxicity
    • scoliosis
    • edema
    • gynecomastia
    • increased CYP450 activity
Octreotide
  • Somatostatin mimetic
  • Mechanism
    • agonist at somatostatin receptors
  • Clinical use
    • acromegaly
    • carcinoid
    • gastrinoma
    • glucagonoma
    • acute esophageal variceal bleed
  • Toxicity
    • GI upset
    • gallstones
    • bradycardia
Oxytocin
  • Mechanism
    • agonist at oxytocin receptor
  • Clinical use
    • stimulation of labor
    • uterine contractions
    • control of uterine hemorrhage after delivery
    • stimulate milk letdown
  • Toxicity
    • fetal distress
    • abruptio placentae
    • uterine rupture
Desmopressin
  • ADH (vasopressin) mimetic
  • Mechanism
    • agonist at vasopressin V2 receptors
  • Clinical use
    • central (pituitary) diabetes insipidus
    • hemophilia A (factor VIII deficiency)
      • increases availability of factor VIII
    • von Willebrand disease
      • increases release of von Willebrand factor from endothelial cells
  • Toxicity
    • GI upset
    • headache
    • hyponatremia
    • allergic reaction


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