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Hypothalamic / Pituitary Drugs

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Topic updated on 05/29/17 7:33pm

Somatropin
  • Growth hormone (GH) mimetic
  • Mechanism
    • agonist at GH receptors
    • increases production of insulin growth factor-1 (IGF-1)
  • Clinical use
    • GH deficiency
    • increase adult height for children with conditions associated with short stature 
      • Turner syndrome
    • wasting in HIV infection
    • short bowel syndrome
  • Toxicity
    • scoliosis
    • edema
    • gynecomastia
    • increased CYP450 activity
Octreotide
  • Somatostatin mimetic
  • Mechanism
    • agonist at somatostatin receptors
  • Clinical use
    • acromegaly
    • carcinoid
    • gastrinoma
    • glucagonoma
    • acute esophageal variceal bleed
  • Toxicity
    • GI upset
    • gallstones
    • bradycardia
Oxytocin
  • Mechanism
    • agonist at oxytocin receptor
  • Clinical use
    • stimulation of labor
    • uterine contractions
    • control of uterine hemorrhage after delivery
    • stimulate milk letdown
  • Toxicity
    • fetal distress 
    • abruptio placentae 
    • uterine rupture
Desmopressin
  • ADH (vasopressin) mimetic
  • Mechanism
    • agonist at vasopressin V2 receptors
  • Clinical use
    • central (pituitary) diabetes insipidus
    • hemophilia A (factor VIII deficiency)
      • increases availability of factor VIII
    • von Willebrand disease
      • increases release of von Willebrand factor from endothelial cells
  • Toxicity
    • GI upset
    • headache
    • hyponatremia
    • allergic reaction


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Qbank (1 Questions)

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(M1.EC.4799) A 33-year-old G1P0 at 39 weeks gestation is admitted to the labor and delivery floor for induction of labor. She feels well and is no acute distress. She is accompanied by her husband. Her past medical history is notable for major depressive disorder and generalized anxiety disorder. She takes sertraline. Her temperature is 99.2°F (37.3°C), blood pressure is 120/75 mmHg, pulse is 95/min, and respirations are 18/min. To initiate labor induction, the obstetrician injects the patient with a hormone that is endogenously made in the hypothalamus and released by the posterior pituitary. This medication is associated with an increased risk of which of the following complications? Topic Review Topic

1. Placental abruption
2. Vasa previa
3. Placenta accreta
4. Preeclampsia
5. Oligohydramnios

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