questions 0

Reye's Syndrome

Author:
Topic updated on 10/26/16 11:32am

Snap Shot
  • A 10-year-old child developed skin papules 5 days ago and was given aspirin for fever. She now presents with vomiting and lethargy. Physical exam shows mild hepatomegaly. Total bilrubin and serum ammonium are elevated.
Introduction
  • Hepatoencephalopathy associated with aspirin ingestion during a a flu-like illness or varicella
    • aspirin metabolites ↓ β-oxidation via reversible inhibition of mitochondrial enzymes
  • Usually 4-12 years of age
  • Acute changes seen in microscopic liver architecture
    • microvesicular fatty change
      • small intra-cytoplasmic fat globules
      • no nuclear displacement
Presentation
  • Symptoms
    • Biphasic course
      • prodrome
        • afebrile (intially)
        • sleepy, lethargic
      • encephalopathy (symptoms in order of increasing intracranial pressure [ICP])
        • vomiting
        • stupor
        • coma
        • death
  • Physical exam
    • hepatomegaly
Evaluation
  • Labs
    • ↑ transaminases
    • hypoglycemia 
    • rest are similar to Fulminant liver failure
Treatment
  • Medical
    • controlling ICP (major cause of death) via
      • mannitol
      • fluid restriction
      • hyperventilation
        • constricts cerebral vasculature
Prognosis, Prevention, Complications
  • Death without aggressive management


  RATE CONTENT
3.0
AVERAGE 3.0 of 3 RATINGS

Qbank (0 Questions)


Recent Videos

video
Reye syndrome – definition, symptoms and pathophysiology
2/7/2016
57 views
5

Evidence & References Show References




Topic Comments

Subscribe status: