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Antacids

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Topic updated on 06/09/17 6:20pm

Introduction
  • Resultant increases in gastric pH and empyting time may affect the action of other drugs via changes in
    • absorption
      • ↑ absorption of weak bases
      • ↓ absorption of weak acids
    • bioavailability
    • urinary excretion
  • Class can cause hypokalemia via alkalinzation of the blood
Aluminum hydroxide
  • Toxicity
    • constipation and hypophosphatemia
    • proximal muscle weakness
    • osteodystrophy
    • seizures
Magnesium hydroxide
  • Toxicity
    • diarrhea
      • note: milk of magnesia is a laxative
    • hyporeflexia
    • hypotension
    • cardiac arrest
      • magnesium is a key ion in cardiac arrhythmias
Calcium carbonate
  • Toxicity
    • belching
    • hypercalcemia
      • can be used as a source of supplemental calcium
    • rebound acid ↑
    • chelation of other drugs
      • e.g. tetracycline


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