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Vitamin K Deficiency

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Topic updated on 08/13/17 10:44pm

Introduction
  • Disruption of all vitamin K-dependent factors
    • II, VII, IX, X, protein C, protein S
  • See Vitamin topic   
  • Deficiency most commonly seen in
    • newborns
      • lack gut colonization by bacteria that produce vitamin K
      • newborns are given IM vitamin K shot at birth for prophylaxis
    • malabsorptive conditions
    • long-term antibiotic therapy
      • kills gut bacteria that produce vitamin K
Presentation
  • Symptoms
    • hemarthroses
    • intramuscular bleeding
    • GI bleeding
    • excessive bleeding in response to minor trauma
Evaluation
  • Labs
    • PTT, PT
    • normal bleeding time
Treatment
  • Administer vitamin K


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