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Coagulation Factor Inhibitor

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Topic updated on 06/09/17 9:55am

Introduction
  • Autoantibody against a coagulation factor
  • Anti-Factor VIII is the most common
    • recall factor VIII is deficient in hemophilia A
Presentation
  • Symptoms
    • hemarthroses
    • intramuscular bleeding
    • GI bleeding
    • excessive bleeding in response to minor trauma
      • indistinguishable from hemophilia
Evaluation
  • Labs
    • PTT
    • normal PT, bleeding time
  • Mixing studies
    • supplied factor does not result in clot formation
      • antibody inhibits supplied factors
    • used to distinguish from hemophilia, which would clot when supplied normal plasma


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