next
questions 0

Innate vs. Adaptive Immunity

Author:
Topic updated on 07/22/16 6:52am

Overview
  • The immune system has two main divisions
    • innate
      • first defense
    • adaptive
      • defense following breach of innate system
  • Integrated response following an immune stimuli
Innate
  • Properties
    • non-specific
    • fast
    • lacks memory
    • germline encoded
      • constant
    • cannot distinguish self from non-self
  • Cells involved
    • neutrophils, monocytes, macrophages, dendritic cells
  • Main components
    • physical
      • skin
      • mucous membranes
    • physiological processes
      • phagocytosis
        • receptors for conserved components pathogens
          • e.g. LPS receptor
      • chemical defenses
        • lysosyme
        • complement
        • interferons
      • inflammation
Adaptive
  • Properties
    • specific
    • slow upon first exposure
      • fast with subsequent exposure
        • due to memory
    • can distinguish self from non-self
    • germline encoded
      • undergoes extensive germline recombination
  • Cells involved
    • T and B lymphocytes, macrophages, dendritic cells
  • Main components
    • circulating antibodies
    • tissue
      • spleen
      • lymph nodes
      • lymph associated tissue
Interactions between Innate and Adaptive systems
  • Antibodies assist in phagocytosis
    • opsonization
  • Antibodies participate in complement
    • classical complement pathway
  • Lymphocytes activate chemical defenses
    • T-lymphocytes secrete chemokines that activate cells of innate immune system

References



  RATE CONTENT
4.0
AVERAGE 4.0 of 3 RATINGS

Qbank (0 Questions)


Recent Videos

video
This video review the adaptive immune response.
2/15/2015
305 views
4

Evidence & References Show References




Topic Comments

Subscribe status: