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Antibody-dependent cell-mediated cytotoxicity (ADCC)

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Topic updated on 04/10/14 3:46pm

Overview
  • A form of immune response that bridges both cell-mediated and humoral immunity 
  • Important in the immune response to parasites.
Activation
  • IgG antibodies coat the surface of target cell  
    • IgE can activate ADCC to destroy invasive helminths
  • Free Fc tail allows binding to Fc-receptor of immune cells
    • CMI cells
      • macrophages
      • NK cells
    • humoral cells
      • neutrophils
      • monocytes
      • eosinophils
  • Fc binding is non-specific
    • specificity mediated through Fab binding
Killing Mechanism
  • Macrophages
    • release lytic enzymes + TNF
  • NK cells
    • release granzymes + TNF + perforin
  • Neutrophils
    • release lytic enzymes
  • Eosinophils
    • release lytic enzymes

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(M1.IM.32) A 27-year old male who works on an organic farm is diagnosed with infection by N. americanus, a helminthic parasite. Eosinophils require which antibody isotype to destroy these parasites via antibody-dependent cellular cytotoxicity? Topic Review Topic

1. IgA
2. IgE
3. IgM
4. IgD
5. IgG

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