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Agglutination

Topic updated on 05/24/17 4:48pm

Introduction
  • Definition
    • conceptually identical to precipitation and denotes
      • antibody complexes with relatively large particles (e.g., RBCs)
        • examples include
          • an antibody binding to a bacterium or RBC which can cause it to clump (agglutinate)
  • Clinical test examples
    • Coombs test
      • an agglutination test which can be divided into
        • direct Coomb test
          • tests for the presence of antibodies found directly on the RBC surface
        • indirect Coomb test
          • tests for the presence of antibodies in the serum
    • Monospot test
      • an agglutination test used in the work-up of Epstein-Barr virus infection
        • which uses horse or sheep substrate


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