questions 2

Coronavirus

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Topic updated on 09/03/17 5:14pm

Snapshot
  • A 64-year-old doctor from China presents to a hospital in Hong Kong with a week history of fever, headache, dry cough, and worsening shortness of breath. He is in Hong Kong on business. Patient is a family practitioner and there is a history of contact with an unprecedented  number of patients presumably suffering from influenza. Temperature is 102°F (39°C).  Patient is admitted to the ICU with contact isolation. He expires shortly thereafter. PCR assay of the post-mortem lung is positive for SARS-CoV. The local health authorities are notified.
Introduction
  • Classification
    • virus
      • RNA 
        • positive-stranded
          • coronavirus
            • coronavirus
              • SARS-CoV
  • Pathogenesis
    • transmission
      • respiratory
      • SARS-CoV also known to be present in urine/feces and sweat
    • reservoir
      • humans
      • birds and small animals known to harbor SARS-CoV
Diseases
  • Common cold
    • coronaviridae are second most common cause of common cold
      • #1 is rhinovirus
    • responsible for about 15% of common colds
    • winter/spring peak incidence
  • SARS (severe acute respiratory syndrome)
    • atypical pneumonia
    • caused by novel coronavirus SARS-CoV
    • 2003 outbreak in Asia and Toronto
Laboratory
  • Characteristics
    • RNA 
      • single-strand
      • positive-sense
      • linear
    • enveloped
    • helical
    • replication in cytoplasm
  • Peplomers on virus surface give appearance like the corona of the sun
    • made of hemagglutinin molecules
  • Diagnose SARS-CoV with antibodies, PCR, or culture
Treatment
  • Self-limiting


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