questions 1

Yersinia pestis

Author:
Topic updated on 09/11/17 3:04pm

Introduction
  • Classification
    • bacteria
      • other Gram-negative
        • zoonotic
          • Yersinia
            • Y. pestis
  • Pathogenesis
    • transmission
      • rodents → fleas → humans → human-to-human
    • reservoir
      • rodents
        • rats
        • squirrels, prarie dogs of southwest U.S.
      • bioterrorism agent
    • molecular biology
      • facultative intracellular
      • resists destruction after phagocytosis by macrophages
        • F1 capsular antigen 
          • antiphagocytic 
        • V and W antigens
          • unique to Yersinia
          • functions unknown
      • endotoxin
      • exotoxin
Diseases
  • Bubonic plague
    • hot red swollen lymph nodes
      • often inguinal nodes (Greek: "bubon" = groin)
      • skin hemorrhages with black discoloration ("black death")
  • Pnuemonic plague
    • pneumonia from septic emboli or inhalation of organisms
    • highly contagious
Laboratory
  • Small Gram-negative rods
  • Bipolar staining
    • ends of rods stain darker than the middle
  • Cultures are hazardous
  • Serology or immunofluorescence to diagnose
  • Coagulase-positive
Treatment
  • Aminoglycosides
  • Killed vaccine and animal control for prevention


  RATE CONTENT
0.0
AVERAGE 0.0 of 0 RATINGS

Qbank (0 Questions)

Sorry, this question is only available for Study Plan members.
Access to 600+ Questions not available in Free Qbank



Evidence & References Show References




Topic Comments

Subscribe status: