questions 3

Viral Genetics

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Topic updated on 04/14/17 8:31pm

Overview
  • Recombination
    • exchange of genes between 2 chromosomes
    • crossing over occurs in homologous regions
  • Reassortment
    • viruses with segmented genomes exchange segments
    • analagous to high-frequency recombination
    • results in influenza pandemics
  • Complementation
    • 2 viruses infect a cell, but one is mutated and has a non-functional protein
    • the nonmutated virus helps the mutant by making protein for both viruses
  • Phenotypic mixing 
    • 2 viruses infect a cell
    • virus A has its own genetic material, but the surface proteins of virus B
    • progeny viruses contain coat components and genetic material from virus A
      • this is because they only had the genetic material from virus A
    • genetic material is not altered
    • pseudovirion formation
      • when a virus's coat is entirely from another virus
      • nucleic acid and coat are completely mismatched


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Qbank (3 Questions)

TAG
(M1.MC.0) A scientist performed an experiment to produce hybrid viruses by mixing two different serotypes of influenza virus, H1N1 and H2N2, in a respiratory epithelium cell line. Several days later, the scientist collected the media and analyzed the viral progeny. She found the following serotypes of virus: H1N1, H2N2, H1N2, and H2N1. Which of the following terms best explains the appearance of new serotypes? Topic Review Topic

1. Recombination
2. Reassortment
3. Complementation
4. Phenotypic mixing
5. Transformation

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TAG
(M1.MC.102) When hepatitis D was injected into an immunocompromised mouse, there was no detectable hepatitis D RNA in the blood at any time point during the next several months. When co-injected with hepatitis B, hepatitis D RNA was was detected in the blood. Which of the following best describes this phenomenon? Topic Review Topic

1. Recombination
2. Reassortment
3. Complementation
4. Phenotypic mixing
5. Transduction

PREFERRED RESPONSE ▶
TAG
(M1.MC.10000) Two viruses, X and Y, infect the same cell and begin to reproduce within the cell. As a result of the co-infection, some viruses are produced where the genome of Y is surrounded by the nucleocapsid of X and vice versa with the genome of X and nucleocapsid of Y. When the virus containing genome X surrounded by the nucleocapsid of Y infects another cell, what is the most likely outcome? Topic Review Topic

1. Virions containing genome X and nucleocapsid Y will be produced
2. Virions containing genome X and nucleocapsid X will be produced
3. Virions containing genome Y and nucleocapsid Y will be produced
4. Virions containing genome Y and nucleocapsid X will be produced
5. No virions will be produced

PREFERRED RESPONSE ▶

Recent Videos

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A video on antigenic shift, direct transfer and reassortment
2/9/2015
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