questions 1

Antifungals

Author:
Topic updated on 01/10/16 1:44pm

Overview
 
Polyenes  
(Bind to ergosterol, forming destructive pores in cell membrane)
 Class Name of Drug(s) Indications
Amphotericin B
  • Amphotericin B
  • Systemic fungal infections
  • Widest spectrum of coverage
Nystatin
  • Nystatin
  • Candida ("swish and swallow")
Blocks Formation of Ergosterol
(A component of fungal cell membrane)
Azoles
(Inhibits fungal CYP450 3A)
Imidazoles
  • Ketoconazole
  • Clotrimazole
  • Miconazole
  • Systemic and superficial infections
  • Wide coverage
Triazoles
  • Fluconazole
  • Itraconazole
  • Voriconazole
  • Systemic and superficial infections
  • Wide coverage
Inhibits Squalene Epoxidase
Terbinafine
  • Terbinafine
  • Dermatophytes (especially nail infections)
Blocks Formation of β-glucan
(A component of fungal cell wall)
Echinocandins
  • Caspofungin
  • Micafungin
  • Anidulafungin
  • Aspergillus
    Candida
Blocks Pyrimidine Synthesis
(Blocks DNA synthesis)
Flucytosine
  • Flucytosine
  • Use with amphotericin B
  • Cryptococcus
    Candida
Other Mechanisms of Action
Griseofulvin
  • Griseofulvin
  • Dermatophytes
Selenium sulfide
  • Selenium sulfide
  • Malassezia
  • All antifungal drugs target the fungal wall or membrane except flucytosine, griseofulvin, and possibly selenium sulfide


  RATE CONTENT
4.0
AVERAGE 4.0 of 2 RATINGS

Qbank (1 Questions)

TAG
(M1.MC.75) A 57-year-old florist presents to his family physician with nodular lesions on his right hand and forearm. He explains that he got pricked by a rose thorn on his right "pointer finger" where the first lesions appeared, and the other lesions then began to appear in an ascending manner. The physician prescribed a medication and warned him of gynecomastia as a side effect if taken for long periods of time. Which of the following is the mechanism of action of the medication? Topic Review Topic

1. Inhibits ergosterol synthesis
2. Binds to ergosterol, forming destructive pores in cell membrane
3. Inhibits squalene epoxidase
4. Inhibits formation of beta glucan
5. Disrupts microtubule function

PREFERRED RESPONSE ▶


Evidence & References Show References




Topic Comments

Subscribe status: