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Griseofulvin

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Topic updated on 05/02/17 4:22pm

Introduction
  • Classification
    • antifungal
      • other
        • griseofulvin
  • Drugs
    • griseofulvin
Mechanism
  • Action
    • fungistatic
    • disrupts microtubule formation
      • prevents mitosis
      • causes arrest at metaphase
    • accumulates in keratin precursor cells and prevents fungal growth there
      • skin, hair, nails
Uses
  • Dermatophytes
  • Oral treatment for superficial infections
  • High fat content diets can increase GI absorption
  • Rarely used in modern medicine
Adverse effects
  • Disulfiram (Antabuse)-like reaction with ethanol
    • can interfere with metabolism of alcohol
    • acetaldehyde accumulates
    • results in nausea and vomiting
  • Avoid in pregnancy
    • teratogenic
  • Carcinogenic
  • Mental confusion
  • Headaches
  • ↑ CYP450 metabolism
    • including ↑ warfarin and OCP metabolism


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