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Interferons

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Topic updated on 03/18/15 4:08pm

Overview
  • Interferons are glycoproteins made by WBCs in response to pathogens
    • interferons are a type of cytokine
  • Mechanism 
    • "interfere" with viral DNA and RNA synthesis
    • induce ribonuclease activity to degrade viral mRNA
    • part of the innate (not the adaptive) immune response
  • Clinical use
    • interferons are produced endogenously, but are also given as drugs
      • interferon-α
        • HBV
        • HCV
        • Kaposi's sarcoma
      • interferon-β
        • multiple sclerosis
      • interferon-γ
        • chronic granulomatous disease
    • can cause neutropenia


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Qbank (1 Questions)

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(M1.MC.67) A 16-year-old Mexican female presents with symptoms of the common cold after the patient's respiratory epithelial cells were infected with Rhinovirus. Due to the presence of the virus, her respiratory epithelial cells begin producing interferon. Which is of the following is LEAST likely to be an outcome of the activation of the interferon response? Topic Review Topic

1. Decreased viral replication within the cell
2. A rhinovirus-specific, cell-mediated immune response
3. Upregulation of NK cell ligands on the infected cell
4. Activation of NK cells
5. Interferon binding to nearby uninfected epithelial cells

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