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Wallerian Degeneration

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Topic updated on 08/22/16 3:22pm

Overview
  • Response to severed axon in PNS
    • the closer the lesion is to the cell body the more likely the neuron will die
  • Cell body response
    • cell swells
    • Nissl substance disappears (chromatolysis)
  • Axon response
    • segment distal to cut degenerates
    • Schwann cells guide regeneration of axon from existing stump
    • peripheral neuron capable of complete regeneration


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