- Defined as excessive growth of androgen-responsive terminal hair in women
- excess hair growth in areas where hair growth is normally minimal
- Defined as masculinization of a woman
- clitoromegaly (pathognomonic)
- deepening voice
- ↑ muscle
- Ovarian (↑ testosterone)
- polycystic ovarian syndrome
- ovarian tumors (Sertoli-Leydig cell tumors)
- Adrenal (↑ DHEA-sulfate)
- congenital adrenal hyperplasia
- Cushing's syndrome
- adrenal tumors
- presumed to be caused by increased androgen-receptor sensitivity
- due to ↓ in steroid-hormone binding globulin (SHBG)
- results in ↑ concentration of free testosterone
- Aromatase deficiency
- inability to convert testosterone to estrogen
- leads to maternal virilization when present in fetus
AVERAGE 5.0 of 1 RATINGS
Qbank (0 Questions)
Level of Evidence 5 and Other Journal Articles (includes Case Reports, Expert Opinions,
Personal Observations, and Biomechanic Studies)
Hunter MH, Sterrett JJ. Polycystic ovary syndrome: it's not just infertility. Am Fam Physician. 2000 Sep 1;62(5):1079-88, 1090.
PMID:10997532 (Link to Abstract)
Belgorosky A, Guercio G, Pepe C, Saraco N, Rivarola MA. Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence. Horm Res. 2009;72(6):321-30. Epub 2009 Oct 21. Review
PMID:19844120 (Link to Abstract)
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