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Pregnancy Labs

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Topic updated on 11/18/16 9:49am

 

 
Urine Estriol
  • Measured in maternal urine
  • Produced by
    • fetal adrenal gland
    • maternal liver
    • placenta
  • Sign of fetal growth
    • ↓ estriol is sign of fetal-maternal-placental dysfunction
α-Fetoprotein (AFP)
  • Measured in maternal serum
  • ↑ AFP
    • associated with open neural tube defects
  • ↓ AFP
    • associated with Down syndrome
Lecithin/Sphingomyelin (L:S) Ratio
  • Measured in amniotic fluid
    • lecithin is a surfactant produced by fetal lungs
    • used to determine maturity of fetal lungs
  • L:S ratio > 2 indicates maturity
  • If L:S ratio < 2
    • administration of cortisol ↑ lecithin production
      • fetus normally produces during the stress of vaginal delivery
    • thyroxine also ↑ lethicin production
    • insulin ↓ production
Triple Screen
  • Test for Down syndrome 
    • ↑ serum β-hCG
    • ↓ serum AFP
    • ↓ urine estriol

 



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