The cervix is composed of simple columnar epithelium in the endocervix and stratified squamous epithelium in the ectocervix. Figure B correctly demonstrates the stratified squamous epithelium that is typical of the ectocervix.
The female reproductive organs are covered by distinct types of epithelium. The ovary is covered with simple cuboidal epithelium, the fallopian tube with simple columnar epithelium, the uterus with simple (pseudostratified) columnar epithelium, and the vagina with stratified squamous non-keratinized epithelium. The cervix is split between the ectocervix covered with stratified squamous epithelium and the endocervix with simple columnar epithelium. The change in epithelial types is observed at the transformation zone (Illustration A).
Chan et al. describe the different female reproductive organs and the epithelium that are associated with them. They further describe detailed procedures for establishing and maintaining primary cultures of human ovarian surface epithelium, oviductal epithelium, and endometrium. For example, they describe that the growth potential of ovarian surface epithelium can be increased by the introduction of viral gene simian virus 40 (SV40) T antigen or the human papilloma virus (HPV) E6/E7.
Reich et al. conducted a systematic review of the developmental origin of cervical and vaginal epithelium and discuss the clinical significance of each. They state that human prenatal epithelialization of the cervix and vagina results in 3 morphogenetically determined units: (i) the Müllerian columnar epithelium of the endocervix, (ii) the Müllerian squamous epithelium of the ectocervix and the upper vagina, and (iii) the vaginal squamous epithelium of the lower vagina.
Illustration A demonstrates the transition zone in the cervix.
Answer 1: Figure A demonstrates simple cuboidal epithelium which is characteristic of ovarian epithelium.
Answer 3: Figure C demonstrates simple columnar epithelium which is characteristic of fallopian tube epithelium.
Answer 4: Figure D demonstrates pseudostratified columnar epithelium which is characteristic of uterine epithelium.
Answer 5: Figure E demonstrates simple cuboidal epithelium which is characteristic of ovarian epithelium.
Chan RW, Mak AS, Yeung WS, Lee KF, Cheung AN, Ngan HY, Wong AS. Human female reproductive tract epithelial cell culture. Methods Mol Biol. 2013;945:347-63. doi: 10.1007/978-1-62703-125-7_21.
PMID:23097117 (Link to Abstract)
Reich O, Fritsch H. The developmental origin of cervical and vaginal epithelium and their clinical consequences: a systematic review. J Low Genit Tract Dis. 2014 Oct;18(4):358-60. doi: 10.1097/LGT.0000000000000023.
PMID:24977630 (Link to Abstract)