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Benign Breast Tumors

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Topic updated on 01/06/16 2:23pm

Snap Shot
  • A 28-year-old female presents with a 2 cm lump in the upper outer quadrant of her left breast. The mass changes in size in keeping with her menstrual cycle.
Introduction
  • Several types
    • fibroadenoma
      • most common tumor in women < 35
      • benign lesion that does not progress to breast cancer
      • size and tenderness varies with estrogen changes 
      • histology shows hypercellular stroma that encircles or compresses ducts 
    • intraductal papilloma
      • small tumor 
      • typically beneath areola in lactiferous sinuses
      • common cause of bloody nipple discharge
    • phyllodes tumor
      • most common in post-menopausal women
      • consists of connective tissue and cysts with "leaf-like" projections
        • derived from stromal cells
      • may progress to malignancy
Presentation
  • Fibroadenoma
    • palpable as a small, mobile, well circumscribed and firm mass
  • Intraductal papilloma
    • serous or bloody nipple discharge
  • Phyllodes tumor
    • large, bulky mass
Evaluation
  • Fine needle aspiration of the mass 


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Qbank (1 Questions)

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(M1.RP.28) A 29-year-old female presents to her physician with a small, well-demarcated mass in her left breast. A biopsy of the lesion is taken and shown in Figure A. Which of the following is associated with the patient’s condition? Topic Review Topic
FIGURES: A          

1. Estrogen related variation in mass size and tenderness
2. Serous nipple discharge
3. Malignancy
4. Caseous necrosis
5. Overexpression of HER-2 receptors

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