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Clomiphene

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Topic updated on 01/06/16 2:25pm

Mechanism
  • Partial estrogen receptor agonist
    • See Female Hypothalamic-Pituitary Axis topic
  • Acts specifically in hypothalamus which antagonizes normal negative feedback inhibition
  • Results in an ↑ release of LH and FSH from pituitary
    • stimulates ovulation
Indications
  • Infertility
  • PCOS 
Toxicity
  • Ovarian enlargement
  • Multiple birth pregnancy
  • Visual disturbances
  • Hot flashes


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