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Sildenafil / Vardenafil

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Topic updated on 05/29/17 5:26pm

Mechanism
  • cGMP phosphodiesterase inhibitor
    • results in less cGMP degradation and ↑ cGMP 
  • Drives smooth muscle relaxation in the corpus cavernosum
    • ↑ blood flow to penis

Indications
  • Erectile dysfunction
  • Pulmonary hypertension
Toxicity
  • Side effects
    • headache
    • flushing
    • dyspepsia
    • impaired blue-green color vision
  • Do not co-administer with nitrates
    • risk of life-threatening hypotension


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Qbank (1 Questions)

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(M1.RP.43) A 57-year-old male presents with a primary complaint of erectile dysfunction. After proper evaluation, the patient is started on daily administration of sildenafil. This medication directly causes accumulation of which of the following intracellular mediators? Topic Review Topic

1. Ca2+
2. cGMP
3. AMP
4. NO
5. ANP

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