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Aromatase Inhibitors

Topic updated on 09/07/17 9:42am

Snapshot
  • A 59-year-old woman with recently diagnosed metastatic estrogen-receptor (ER) positive and human epidermal growth factor 2 (HER2) negative breast cancer presents for follow-up care. She is hormone therapy naive and has non-visceral involvement of the cancer. She is started on letrozole.
Introduction
  • Mechanism of action
    • inhibits peripheral conversion of androgens to estrogens via aromatase inhibition
  • Clinical use
    • estrogen-receptor positive breast cancer
  • Toxicity
    • menopausal symptoms
    • fatigue
  • Medications
    • letrozole
    • anastrozole
    • exemestane


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