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Bartter Syndrome

Topic updated on 05/26/13 1:24pm

Introduction
  • Inability of Na+K+2Cl- contransport pump to resorb chloride in the distal ascending limb
    • results in loss of Na+, K+, Cl- in urine
      • resembles action of loop diuretic
    • loss of K+stimulates production of prostaglandins
      • indirectly results in ↑ secretion of renin, aldosterone
  • Seen mainly in children
Presentation
  • Physical exam
    • normotensive
    • muscle weakness
      • result of hypokalemia
Evaluation
  • Serology
    • hyponatremia
    • hypokalemia
    • metabolic alkalosis
      • due to absorbtion of Na+ in the collecting duct in exchange for H+
Treatment
  • K+-sparring diuretic
  • NSAID
    • ↓ production of prostaglandins


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