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(M2.ON.44) A 63-year-old female presents to clinic. She has a history of gallbladder carcinoma which was diagnosed after presenting with abdominal pain and jaundice. Exploratory laparotomy revealed gallbladder carcinoma that had invaded the liver. The patient was treated with cholecystectomy, partial hepatectomy, and a lymph node dissection with adjuvant chemotherapy. Which of the following is the greatest risk factor for the development of gallbladder carcinoma? Topic Review Topic

1. African-American race
2. Chronic cholecystitis
3. Smoking
4. Chronic alcohol ingestion
5. Chronically low BMI

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