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Memory

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Topic updated on 04/10/14 3:38pm

Memory overview
  • Purpose 
    • allows body to maintain a low number of primed cells
    • allows for altered response to repeat stimulus
  • Primary immune response
    • takes 5-10 days
    • smaller response
    • IgM then IgG
  • Secondary immune response
    • takes 1-3 days
    • greater response
    • high antibody specificity for protein antigens
    • IgA, E, G
      • NO IgM
  • Occurs both in B and T lymphocyte populations
  • Return to type of tissue where antigen was presented initially
    • mediated through specific adhesion molecules
      • e.g. can return to gut if first encountered there        
Memory B lymphocytes
  • Activation of B-cell by antigen promotes differentiation into plasma cell
  • Memory B-cells are a distinct population
    • have undergone isotype switching
      • express IgA, E, G on surface
        • naive B-cells express IgM, IgD
    • enter resting cell stage
    • have affinity for antigen
Memory T lymphocytes
  • Activation-induced cell death (AICD)
    • active process of repressing T-cell function following an immune stimulus
    • mediated via Fas ligand
    • apoptosis of T-cell
    • leaves memory population while killing effector population
  • Memory cell characteristics
    • decreased IL-2 receptor
      • as opposed to effector B-cell with high IL-2 receptor
    • have high affinity for antigen

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